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RAS BiologyБиофизика Biophysics

  • ISSN (Print) 0006-3029
  • ISSN (Online) 3034-5278

Octacalcium Phosphate Doped with Barium Cations for Application in Tissue Engineering

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PII
S0006302925020124-1
DOI
10.31857/S0006302925020124
Publication type
Article
Status
Published
Authors
I. S Fadeeva
  • Affiliation:
    A.A. Baykov Institute of Metallurgy and Materials Science, Russian Academy of Sciences
    Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences
M. V. Kozlova
  • Affiliation: A.A. Baykov Institute of Metallurgy and Materials Science, Russian Academy of Sciences
Volume/ Edition
Volume 70 / Issue number 2
Pages
333-346
Abstract
The objective of the study was to investigate the impact of barium cation doping on the phase and structural properties of octacalcium phosphate powder synthesized via a low-temperature method, along with its biocompatibility, particularly under in vitro circumstances that mimic inflammation. It was revealed that doping with Ba2+ cations in the concentration range used (1, 5 and 10 calculated %) does not interfere with the lowtemperature chemical transformation of DPCD and its transformation into OCP, however, the percentage of real substitution is at a maximum of 6.7 at.%. The results of in vitro studies confirm that the substitution of Ca2+ for Ba2+ in the structure of OCP does not affect its cytotoxic properties and all the studied variants of low-temperature OCP and its Ba-substituted variants at the recommended concentration of 1 mg/ml do not have a cytotoxic effect and are biocompatible. The effects revealed for OCP-Ba10, namely the absence of an effect on the content of lysosomes and ROS in human macrophages under normal conditions and a significant decrease in ROS production under inflammatory conditions, as well as a significant increase in the constitutive activation of T-lymphocytes, indicate that these processes are directly and dose-dependently associated with Ba2+ cations in the composition of OCP. The proposed approach of low-temperature chemical transformation of Ba2+-substituted variants of OCP is promising and is of interest for obtaining CPC materials with specified properties. The obtained Ba2+-substituted variants of OCP are safe and biocompatible, and the most effective variant of OCP with a maximum degree of Ca2+ substitution by Ba2+ 10% (OCP-Ba10) is bioactive and has potential antioxidant and immunomodulatory effects.
Keywords
биокерамика остеопластические материалы низкотемпературная химическая трансформация фосфаты кальция октакальцийфосфат допирование барий-замещенные фосфаты кальция
Date of publication
24.10.2025
Year of publication
2025
Number of purchasers
0
Views
21

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