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RAS BiologyБиофизика Biophysics

  • ISSN (Print) 0006-3029
  • ISSN (Online) 3034-5278

In vitro Interaction of Titin and Myosin-Binding Protein C

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PII
S30345278S0006302925030012-1
DOI
10.7868/S3034527825030012
Publication type
Article
Status
Published
Authors
T.A. Uryupina
  • Affiliation: Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences
M.A. Timchenko
  • Affiliation: Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences
L.G. Bobyleva
  • Affiliation: Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences
N.V. Penkov
  • Affiliation: Institute of Cell Biophysics, Russian Academy of Sciences
A.G. Gabdulkhakov
  • Affiliation: Institute of Protein Research, Russian Academy of Sciences
P.V. Nekrasov
  • Affiliation: Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences
S.N. Udalsov
  • Affiliation: Institute of Physicochemical and Biological Problems of Soil Science
I.M. Vikhlyantsev
  • Affiliation:
    Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences
    Pushchino Branch of the Russian Biotechnological University (BIOTECH University)
A.G. Bobylev
  • Affiliation:
    Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences
    Sirius University of Science and Technology
Volume/ Edition
Volume 70 / Issue number 3
Pages
421-429
Abstract
The morphological and structural features of coaggregates of two muscle proteins of the sarcomeric cytoskeleton (titin and myosin-binding protein C) were studied using atomic force microscopy, FTIR spectroscopy, fluorimetry using the dye thioflavin T and X-ray diffraction. It was found that, depending on the ionic strength of the solution, coaggregation of these proteins occurs with the formation of structures with different morphologies. The data obtained in vitro expand the understanding of the peculiarities of aggregation of sarcomeric muscle proteins and are important for a better understanding of their interaction in sarcomeres in vivo.
Keywords
мультидоменные мышечные белки миозин-связывающий белок С титин агрегация атомно-силовая микроскопия
Date of publication
07.05.2025
Year of publication
2025
Number of purchasers
0
Views
47

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