- PII
- S30345278S0006302925040027-1
- DOI
- 10.7868/S3034527825040027
- Publication type
- Article
- Status
- Published
- Authors
- Volume/ Edition
- Volume 70 / Issue number 4
- Pages
- 646-651
- Abstract
- The effect of the peptide Thr-Ser-Lys-Tyr isolated from the brain of the obligate hibernating long-tailed ground squirrel Urocitellus undulatus (formerly Citellus undulatus, Spermophilus undulatus) on the polymerization/depolymerization of actin in vitro was studied by electron microscopy. Upon incubation of the peptide with globular (monomeric) actin at concentrations of 0.1 mg/ml (in a ratio of 1 : 1), the formation of single filaments of actin was observed. When the peptide was added to the formed actin filaments, no effects were observed, in particular, actin depolymerization. The possible involvement of the peptide in the polymerization of actin in vivo and a possible contribution to the restoration of the functional activity of the central nervous system after the hibernating animal leaves the state of hypothermia are discussed.
- Keywords
- актин пептид Thr-Ser-Lys-Tyr электронная микроскопия гибернация память
- Date of publication
- 15.12.2025
- Year of publication
- 2025
- Number of purchasers
- 0
- Views
- 37
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