- PII
- S0006302925010134-1
- DOI
- 10.31857/S0006302925010134
- Publication type
- Article
- Status
- Published
- Authors
- Volume/ Edition
- Volume 70 / Issue number 1
- Pages
- 112-121
- Abstract
- Nanosized materials are widely used in biomedical nanotechnologies, but the mechanisms of toxic effects of metal and non-metal nanoclusters remain unclear. The aim of this work is to evaluate the size characteristics and mechanisms of toxic action of silver, selenium, and cobalt nanoparticles at the level of isolated mitochondria. Using the laser ablation method, silver (rounded, ~10–20 nm and ~50 nm), cobalt (cubic and prismatic, ~100–200 nm), and selenium (spherical, ~20–30 nm and 135–180 nm) nanoparticles with different spectral characteristics and capable of forming conglomerates were obtained. Silver, cobalt, and selenium nanoparticles (0.1–10 μg/ml) effectively inhibited the respiratory activity of isolated rat liver mitochondria by disrupting the coupling of oxidation and phosphorylation, which was accompanied by a drop in the mitochondrial membrane potential. The uncoupling effect of nanoparticles may be associated with the transfer of electrons from the electron transport chain of mitochondria to the positively charged surface of nanoparticles and depends on the size and material of the nanoparticles.
- Keywords
- наночастицы токсическое действие митохондриальные мембраны ингибирование респираторная активность
- Date of publication
- 24.10.2025
- Year of publication
- 2025
- Number of purchasers
- 0
- Views
- 19
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