- PII
- S0006302925010142-1
- DOI
- 10.31857/S0006302925010142
- Publication type
- Article
- Status
- Published
- Authors
- Volume/ Edition
- Volume 70 / Issue number 1
- Pages
- 122-128
- Abstract
- It has been demonstrated that nitrosonium cation (NO+) transformation as a constituent of sodium nitroprusside into NO molecule under action of sodium dithionite as a strong reducer did not result in full supression of cytotoxic activity of nitroprusside solution as NO+ donor on the culture of MCF-7 tumour cells. As a matter of fact, NO molecules and Fe2+ ions released from SNP at this conditions formed dinitrosyl iron complexes with thiol-containing ligands (thiol-containing proteins or thiosulphate anions appeared from decomposed dithionite).The half of nitrosyl ligands in the complexes represented also as in nitroprusside in cytotoxic NO+ form. Nevertheless because the amount of dinitrosyl iron complexes was three times less than that of initial nitroprusside the cytotoxic effect of nitroprusside solution as NO+ donors sharply decreased under action of dithionite on nitroprusside.
- Keywords
- нитропруссид катион нитрозония динитрозильные комплексы железа цитотоксикоз
- Date of publication
- 24.10.2025
- Year of publication
- 2025
- Number of purchasers
- 0
- Views
- 17
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