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  • ISSN (Print) 0006-3029
  • ISSN (Online) 3034-5278

M-Cholinergic Brain Reaction in Dependence on the Environmental Temperature for Cold-Blooded and Warm-Blooded Animals

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PII
S0006302925020102-1
DOI
10.31857/S0006302925020102
Publication type
Article
Status
Published
Authors
S. N Kalabushev
  • Affiliation:
    Institute of Functional Genomics, Lomonosov Moscow State University
    V.A. Negovsky Scientific Research Institute of General Reanimatology
D. N Voronkov
  • Affiliation: Research Center of Neurology
Yu. S Mednikova
  • Affiliation: Institute of Higher Nervous Activity and Neurophysiology, Russian Academy of Sciences
Volume/ Edition
Volume 70 / Issue number 2
Pages
314-327
Abstract
During artificial incubation of slices of the sensorimotor cortex of guinea pigs and the telencephalon of turtles, microionophoretic application of acetylcholine to neurons revealed a significantly lower frequency of spike responses in the nerve cells of turtles compared with guinea pig cells. This difference was attributed to the different rate of M-cholinergic response in the temperature ranges of 27–29°C and 34–36°C, as found previously in hypothermic experiments. Although experiments on guinea pig and turtle neurons were performed in the same temperature range (32–34°C), the genetically determined structure of neuronal membranes reflects the natural temperature dependence of both species: guinea pig membranes with a constant habitat temperature of 38°C have a higher density of К+ channels than turtles with a preferred temperature of 28–32°C. The difference in К+ channel representation was determined by a significantly longer activation aftereffect in turtle neurons in response to glutamate-induced spike activation. The low density of К+ channels on membranes and the low rate of the M-cholinergic response, which closes them at the onset of any adaptive act, prevent neurons from forming high-frequency and long-lasting impulse sequences to regulate behavior over a wide range in turtles with a preferred temperature of 28–32°C.
Keywords
черепахи морские свинки ацетилхолин глутамат импульсная активность нейронов температура скорость реакции
Date of publication
24.10.2025
Year of publication
2025
Number of purchasers
0
Views
18

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