- PII
- S0006302925020146-1
- DOI
- 10.31857/S0006302925020146
- Publication type
- Article
- Status
- Published
- Authors
- Volume/ Edition
- Volume 70 / Issue number 2
- Pages
- 354-358
- Abstract
- The problem of purinergic regulation in synapses of phasic and tonic muscles of warm-blooded animals was investigated. For this purpose, the effect of the cotransmitter of the main mediator, ATP, and its persistent metabolite, adenosine, on the contraction of various oculomotor systems of the rat, the lateral rectus (tonic) and circular (phasic) muscles of the eye, was evaluated. ATP potentiated the carbacholine-evoked contraction of the rat lateral rectus muscle by a quarter, while this purine, on the contrary, significantly inhibited the carbacholine-evoked contraction of the circular eye muscle. No significant manifestation of the modulatory effect of adenosine on the carbacholine-evoked contraction of the muscles under study was revealed. The results obtained indicate a multidirectional postsynaptic effect of ATP on phasic and tonic oculomotor systems.
- Keywords
- круговая мышца глаза латеральная прямая мышца глаза АТФ карбахолин механомиография мышечное сокращение
- Date of publication
- 24.10.2025
- Year of publication
- 2025
- Number of purchasers
- 0
- Views
- 18
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