- PII
- S30345278S0006302925040071-1
- DOI
- 10.7868/S3034527825040071
- Publication type
- Article
- Status
- Published
- Authors
- Volume/ Edition
- Volume 70 / Issue number 4
- Pages
- 690-698
- Abstract
- The state of mitochondria in neurons of the lateral vestibular nucleus of Deiters in mice after 8-hour vestibular stimulation was studied. It was shown that an hour after stimulation, significant changes occurred in the mitochondria of Deiters neurons: an increase in area, a disruption in the structure of cristae, and the presence of mitophagosomes. At the same time, the mRNA levels of proteins-markers of mitochondrial biogenesis (PGC-1α), their division (DRP-1), and fusion of the outer and inner mitochondrial membranes (MFN1, MFN2, OPA) increased, indicating activation of mitogenesis in Deiters neurons as a result of stimulation of the vestibular system. The administration of betahistine 30 minutes before stimulation at a dose of 300 mg/kg prevented mitochondrial disorders and the formation of mitophagosomes. The obtained data indicate that under increased vestibular stimulation, Deiters neurons can undergo significant damage. The revealed mechanisms of mitochondrial damage allow us to define a potential strategy for the treatment of diseases associated with impaired mitochondrial dynamics (e.g., neurodegenerative diseases or ischemia).
- Keywords
- нейроны латерального вестибулярного ядра стимуляция бетагистин митохондрии ультраструктура экспрессия генов
- Date of publication
- 13.12.2025
- Year of publication
- 2025
- Number of purchasers
- 0
- Views
- 42
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