Stochastic Modeling of Energy Balance in MCF-7 Breast Cancer Cells Taking into Account Transposon Activity and Different Methylation States

Pavlov, S.R.; Kanov, E.V.; Razgulyaeva, D.N.; Gursky, V. V

doi:10.7868/S3034527825040157

PII

S30345278S0006302925040157-1

DOI

10.7868/S3034527825040157

Publication type

Article

Status

Published

Authors

S.R. Pavlov

Affiliation: Peter the Great St. Petersburg Polytechnic University

E.V. Kanov

Affiliation: St. Petersburg State University

D.N. Razgulyaeva

Affiliation: Peter the Great St. Petersburg Polytechnic University

V. V Gursky

Affiliation: Ioffe Institute

Volume/ Edition

Volume 70 / Issue number 4

Pages

757-770

Abstract

Cancer cells exhibit increased activity of mobile genetic elements (transposons). A possible anticancer strategy involves exploiting the energy costs associated with abnormal activity of these elements to create conditions of energy starvation within the cell and initiate cell death programs. Here, we propose a stochastic model of energy balance in a cell population considering the energy expenditure associated with retrotransposition of LINE-1 and SINE mobile elements. Parameter values in the model were derived from published data and new experimental measurements of ATP quantities in MCF-7 cells under normal and hypomethylation conditions. Numerical stochastic simulations generated distributions of variables representing the number of mRNA molecules, proteins participating in principal energy-intensive cellular processes, and the number of active LINE-1 and SINE retrotransposons in the genome. Energy expenditure distributions across major cellular processes were also calculated under stationary conditions. Results show that low-energy costs linked to retrotransposition of mobile elements under normal conditions rise considerably upon perturbation of model parameters. These findings could inform practical scenarios influencing energetically mediated initiation of cell death programs in cancer cells through activation of mobile elements.

Keywords

мобильные генетические элементы MCF-7 ретротранспозоны LINE-1 SINE биоэнергетика клетки стохастическое моделирование онкология

Date of publication

13.12.2025

Year of publication

2025

Number of purchasers

Views

References

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GOST	Gursky V., Kanov E., Pavlov S., Razgulyaeva D. Stochastic Modeling of Energy Balance in MCF-7 Breast Cancer Cells Taking into Account Transposon Activity and Different Methylation States // Biophysics. – 2025. – V. 70. – Issue number 4 C. 757-770 . URL: https://biophysras.ru/s30345278s0006302925040157-1/?version_id=117883. DOI: 10.7868/S3034527825040157
MLA	Gursky, V. V, Kanov, E.V, Pavlov, S.R, Razgulyaeva, D.N "Stochastic Modeling of Energy Balance in MCF-7 Breast Cancer Cells Taking into Account Transposon Activity and Different Methylation States." Biophysics. 70.4 (2025).:757-770. DOI: 10.7868/S3034527825040157
APA	Gursky V., Kanov E., Pavlov S., Razgulyaeva D. (2025). Stochastic Modeling of Energy Balance in MCF-7 Breast Cancer Cells Taking into Account Transposon Activity and Different Methylation States. Biophysics. vol. 70, no. 4, pp.757-770 DOI: 10.7868/S3034527825040157

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Stochastic Modeling of Energy Balance in MCF-7 Breast Cancer Cells Taking into Account Transposon Activity and Different Methylation States

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Stochastic Modeling of Energy Balance in MCF-7 Breast Cancer Cells Taking into Account Transposon Activity and Different Methylation States

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